Before you begin treatment with Zoladex injection, inform your doctor of:, All the prescription and over-the-counter medications you take, Your allergies, Your health conditions and past medical history, Your pregnancy or breastfeeding status, Your tumor symptoms may worsen during the first few weeks of receiving Zoladex and may include blockages in the ureters and spinal cord compression., Men who receive GnRH analogs may develop high blood sugar and may become at risk for diabetes. Blood sugar levels should be monitored., Heart attacks, sudden cardiac death, and stroke have occurred in men who received treatment with GnRH analogs. Patients should be monitored., Patients with bone cancer who are receiving Zoladex may develop high calcium levels in the blood., Hypersensitivity reactions can occur in some patients who receive Zoladex., A heart rhythm disorder known as QT prolongation can occur with the use of Zoladex., Injection site reactions can occur with Zoladex administration., Depression or worsening depression may occur in women who use GnRH agonists., Cervical resistance can occur during treatment with Zoladex. All the prescription and over-the-counter medications you take, Your allergies, Your health conditions and past medical history, Your pregnancy or breastfeeding status