Omeprazole and sodium bicarbonate is a combination drug used: For short-term treatment of active duodenal ulcers, For short-term treatment of active benign gastric ulcers, For the treatment of gastroesophageal reflux disease (GERD), To maintain the healing of erosive esophagitis, To decrease the risk of upper gastrointestinal bleeding in patients who are critically ill Fact Table Formula C17H19N3O3S License US DailyMed Bioavailability 35–76% Legal status US: OTC / Rx-only Chemical Name Omeprazole Elimination half-life 39.5 days Dosage (Strength) 20mg/1100mg, 40mg/1100mg Pregnancy Consult Doctor Brands Zegerid Protein binding 95% PubChem CID 4594 MedlinePlus a693050 ChEBI 7772 ATC code A02BC01 DrugBank DB00338 KEGG D00455 Routes of administration By mouth

Zegerid (Omeprazole and sodium bicarbonate)

Omeprazole and sodium bicarbonate is available in a capsule and as a powder for oral suspension. The strengths are 20 mg and 40 mg. Follow the instructions on the prescription label. Dosing for the short-term treatment of an active duodenal ulcer: 20 mg by mouth once daily for 4 weeks Dosing for the short-term treatment of an active benign gastric ulcer: 40 mg by mouth once daily for 4 to 8 weeks Dosing for GERD (no erosive esophagitis): 20 mg by mouth once daily for up to 4 weeks Dosing for GERD (erosive esophagitis): 20 mg by mouth once daily for 4 to 8 weeks Dosing to maintain the healing of erosive esophagitis: 20 mg by mouth once daily Dosing to reduce the risk of upper gastrointestinal bleeding in patients who are critically ill (40 mg oral suspension only): 40 mg by mouth to start, then 40 mg by mouth 6 to 8 hours later and 40 mg by mouth once daily thereafter for 2 weeks
Before you start taking omeprazole and sodium bicarbonate, inform your doctor:, Of your allergies, Of all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements, Of your medical conditions, If you are pregnant or plan to become pregnant, If you are breastfeeding or plan to breastfeed, Although you may achieve symptomatic relief with omeprazole and sodium bicarbonate, it does not rule out the presence of gastric cancer., Long-term treatment with omeprazole and sodium bicarbonate may cause atrophic gastritis., Omeprazole and sodium bicarbonate can cause kidney inflammation., Long-term treatment with omeprazole and sodium bicarbonate can cause vitamin B-12 deficiency., Omeprazole and sodium bicarbonate can increase the risk of diarrhea associated with C. difficile., Do not take omeprazole and sodium bicarbonate with clopidogrel, St. John's Wort, or rifampin., Long-term treatment with omeprazole and sodium bicarbonate can increase the risk for hip, wrist, or spinal fractures., Long-term treatment with omeprazole and sodium bicarbonate can cause low magnesium levels., Omeprazole and sodium bicarbonate can interfere with diagnostic investigations for Neuroendocrine Tumors. Of your allergies, Of all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements, Of your medical conditions, If you are pregnant or plan to become pregnant, If you are breastfeeding or plan to breastfeed

Zegerid (Omeprazole and sodium bicarbonate)

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