Use of Xeljanz XR may not be suitable for people with any history of liver disease (especially hepatitis B or C), kidney disease or renal failure, heart problems for those over 50, lung disease, blood clots, chronic infections, HIV, intestinal problems (like ulcers or diverticulitis), or diabetes. You should postpone or temporarily discontinue use of Xeljanz XR if you are planning to take a vaccine. Discuss this with your doctor before discontinuing use. Tell your doctor if you have hadtuberculosisbefore beginning on Xeljanz XR. Do not take Xeljanz XR is you are pregnant or planning to become pregnant unless your doctor approves it.