Common adverse reactions may include: Abdominal distress, Abnormal cranial sensation, Acne vulgaris, Agranulocytosis, Alopecia, Anemia, Anorexia, Aphasia, Aphthous, Aplastic, Arterial thrombosis, Arthralgia, Azotemia, Blurred vision, Bone fracture, Bone marrow depression, Burning sensation of the skin, Cerebral thrombosis, Chemical arachnoiditis chills, Chest pain, Chronic obstructive pulmonary disease, Cognitive dysfunction, Conjunctivitis, Cough, Cryptococcosis, Cystitis, Cytomegalovirus disease, Decreased libido, Decreased serum albumin, Deep vein thrombosis, Defective oogenesis, Defective spermatogenesis, Dermal ulcer, Dermatitis, Diabetes mellitus, Diaphoresis, Diarrhea, Dizziness, Drowsiness, Dysarthria, Dyschromia, Dysuria, Ecchymoses, Enteritis, Eosinophilia, Epistaxis, Erythema multiforme, Erythematous rash, Exacerbation of psoriasis, Exfoliative dermatitis, Eye pain, Fatigue, Fever, Furunculosis, Gastrointestinal hemorrhage, Gastrointestinal ulcer, Gingivitis, Gynecomastia, Headache, Hematemesis, Hematuria, Hemiparesis, Hepatic failure, Hepatitis, Herpes simplex infection, Herpes zoster, Histoplasmosis, Hypogammaglobulinemia, Hypotension, Impotence, Increased liver enzymes, Infection, Infertility, Interstitial pneumonitis, Intestinal perforation, Leukoencephalopathy, Leukopenia, Lymphadenopathy, Lymphoproliferative disorder, Malaise, Malignant lymphoma, Melena, Menstrual disease, Mood changes, Myalgia, Myelopathy, Nausea, Neutropenia, Nocardiosis, Nodule, Non-Hodgkin's lymphoma, Non Immune anaphylaxis, Oligospermia, Osteonecrosis, Osteoporosis, Pancreatitis, Pancytopenia, Paresis, Pericardial effusion, Pericarditis, Pharyngitis, Pneumonia, Polyarticular juvenile idiopathic arthritis, Proteinuria, Pruritus, Psoriasis, Pulmonary alveolitis, Pulmonary embolism, Pulmonary fibrosis, Respiratory failure, Retinal thrombosis, Rheumatoid arthritis, Seizure, Sepsis, Severe neurotoxicity, Skin necrosis, Skin photosensitivity, Skin rash, Speech disturbance, Stevens-Johnson syndrome, Stomatitis, Stomatitis, Thrombocytopenia, Thrombophlebitis, Tinnitus, Tissue necrosis, Transient blindness, Tumor lysis syndrome, Upper respiratory tract infection, Vaccinia, Vaginal discharge, Vasculitis, Vomiting