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Xarelto (Rivaroxaban)
XARELTO (Rivaroxaban) is a medication used to treat or prevent blood clots in a number of different medical conditions. Blood clots that form in the deep vein system may break off and become lodged in the capillaries of the lungs, brain, or other organs. Damage from blood clots may be permanent and can be fatal. Xarelto may be prescribed for the following: Prevent stroke and systemic embolism in nonvalvular atrial fibrillation, Prevent deep vein thrombosis (DVT) in patients undergoing knee or hip replacement surgery, Prevent recurrence of deep vein thrombosis (DVT) or pulmonary embolism (PE), Treat deep vein thrombosis (DVT) and pulmonary embolism (PE) XARELTO (Rivaroxaban) works by preventing the function of the clotting factor Xa. The body forms clots through a complex system of proteins called clotting factors, and by inhibiting factor Xa, XARELTO (Rivaroxaban) slows the formation of blood clots. Fact Table Formula C19H18ClN3O5S License US FDA, EU EMA, US DailyMed Bioavailability 80–100% Legal status Rx-Only Chemical Name Rivaroxaban Elimination half-life 5–9 hours Dosage (Strength) 2.5mg, 10mg, 15mg, 20mg Pregnancy Consult Doctor Brands Xarelto Protein binding 92% to 95% PubChem CID 6433119 MedlinePlus a611049 ChEBI 68579 ATC code B01AF01 DrugBank DB06228 KEGG D07086 Routes of administration By mouth

Xarelto (Rivaroxaban)

  • The dosage of XARELTO (Rivaroxaban) depends on the condition being treated and how well the kidney is functioning. XARELTO (Rivaroxaban) should be prescribed at the following doses: Nonvalvular Atrial fibrillation: 20 mg once daily with food, Treatment of DVT, PE, and reduction of recurrence: 15 mg twice daily with food for 21 days and then 20 mg once daily with food thereafter, Prophylaxis of DVT following hip or knee surgery: 10 mg once daily with or without food Doses 15 mg or higher should be taken with food to improve absorption. Doses below 15 mg can be taken with or without food. If you have impaired kidney function, your doctor may prescribe a reduced dose.
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