Vivelle Dot (Estradiol)

All estrogen therapies carry risk because they can increase the chances of getting cancer of the uterus (womb). You should report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Do not use estrogens (with or without progestins) to prevent heart disease, heart attacks or strokes. Using estrogens (with or without progestins) may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens may increase your risk of dementia (decline in memory and thinking skills). VIVELLE DOT (estrogen therapy) should not be used if you: are allergic to CombiPatch or any of its ingredients, have unusual vaginal bleeding, currently have or have had certain cancers, including cancer of the breast or uterus, had a stroke or heart attack in the recent past (for example, in the past year), currently have or have had blood clots, currently have or have had liver problems, may be pregnant high blood pressure, angina, or heart disease, high cholesterol, liver disease, kidney disease, asthma, epilepsy or other seizure disorder, migraines, diabetes, depression, gallbladder disease, if you have had your uterus removed (hysterectomy)

All medications may cause side effects, but usually patients have no, or minor, side effects. Common side effects of VIVELLE DOT may include: headaches, breast tenderness, back pain nausea, vomiting, loss of appetite;, swollen breasts;, acne or skin color changes;, decreased sex drive, impotence, or difficulty having an orgasm;, migraine headaches or dizziness;, vaginal pain, dryness, or discomfort;, swelling of your ankles or feet;, depression; or, changes in your menstrual periods, break-through bleeding chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling, sudden numbness or weakness, especially on one side of the body, sudden severe headache, confusion, problems with vision, speech, or balance, pain or swelling in your lower leg, abnormal vaginal bleeding, pain, swelling, or tenderness in your stomach, jaundice (yellowing of the skin or eyes), a lump in your breast