If you are using Truvada with consultation from your doctor, then you should keep the fact in mind that he has weighed the pros and cons of the medicine before prescribing them to you. There are a few side effects of using Truvada. You need to look out for the following and consult a doctor if these persist: Diarrhea, Headache, Dizziness, Trouble sleeping, Back pain, Change in the color of the skin on your palms or soles, Signs of a certain nerve problem known as Guillain-Barre syndrome, Liver and blood problems It is very rare to develop an allergic reaction to Truvada. However, if such a situation arises, get medical assistance immediately. If you notice anything other than the above-listed side effects, you should contact your physician.