Your doctor may prescribe Treximet to treat migraine headaches with or without aura. It contains two active ingredients: naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and sumatriptan, a selective serotonin receptor agonist. Naproxen helps relieve pain and reduce inflammation, while sumatriptan constricts blood vessels in the brain and blocks the release of certain substances that cause migraine symptoms. Fact Table Formula C32H40N3NaO9S License US FDA, EU EMA, US DailyMed Bioavailability 15%(Sumatriptan), 95%(Naproxen) Legal status Rx-Only Chemical Name Naproxen/Sumatriptan Elimination half-life 2.5 hours(Sumatriptan), 12–17 hours (Naproxen), Dosage (Strength) 85mg/500mg (Generic) Pregnancy Not Recommended Brands Treximet Protein binding 14–21%(Sumatriptan), 99%(Naproxen) PubChem CID 23709079 MedlinePlus a601116 ChEBI 10650 ATC code None DrugBank DB00669 KEGG D11577 Routes of administration By mouth
Treximet (Naproxen/Sumatriptan)
- The recommended dose is one tablet by mouth with water at the onset of a migraine headache. If the headache returns, a second tablet may be taken at least two hours after the first dose. The maximum daily dose is two tablets in 24 hours. Do not exceed the recommended dosage or take this medication more often than prescribed.
