Trelegy Ellipta (Fluticasone Furoate / Umeclidinium / Vilanterol Trifenatate)

Fluticasone Fumarate Fluticasone fumarate is an inhaled corticosteroid (ICS) which works by reducing inflammation in the cells of the lungs. Inflammation narrows the passages of the lungs and makes it difficult to breathe. In patients with COPD, cells of the immune system are overactive and ICSs help to reduce inflammation and make breathing easier. Umeclidinium Umeclidinium is a long-acting muscarinic antagonist (LAMA) or anticholinergic medication. Anticholinergics work by binding to smooth muscle cells of the lungs and relaxing the airways. Vilanterol Vilanterol is a long-acting beta-agonist (LABA). Vilanterol works by attaching to beta-receptors, which are located on the surface of smooth muscle cells in the lungs. By attaching to beta-receptors, vilanterol increases levels of the signaling molecule cyclic AMP (cAMP) and causes the muscles of the lungs to relax.

Do not use TRELEGY ELLIPTA for acute bronchospasm or the treatment of asthma. If you are having trouble breathing, a rescue inhaler, like albuterol, should be used for immediate relief. TRELEGY ELLIPTA is a chronic medication and takes several days of regular use to begin working. TRELEGY ELLIPTA may increase the risk of pneumonia in patients with COPD. Use with caution if you have a chronic infection, fungal, viral, bacterial, tuberculosis, ocular herpes, or other chronic infections. Tell your doctor if you have a history of heart problems. Tell your doctor if you have a history of or current narrow-angle glaucoma as TRELEGY ELLIPTA may worsen the condition. TRELEGY ELLIPTA may worsen urinary retention in patients who have bladder-neck obstruction or benign prostatic hyperplasia. TRELEGY ELLIPTA has the potential to interact with many different medical conditions. Speak with your doctor or pharmacist for a full list of precautions.

The most common adverse effect of TRELEGY ELLIPTA may include: Back pain, Cough, Diarrhea, Dysgeusia, Gastroenteritis, Headache, Oropharyngeal Pain Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy.Read More....