Possible serious side effects include: * Heart Problems. Tell your doctor if you feel very tired, are short of breath, or have swollen feet and ankles.* Rare life-threatening events: hole in stomach or bowel wall (perforation) or bleeding from the tumor. Both of these side effects could cause symptoms such as painful, swollen abdomen, vomiting blood, and black, sticky stools. Your doctor can tell you other symptoms to watch for.* Increased blood pressure. Your doctor may check your blood pressure. You may need treatment for high blood pressure. Common side effects: * Feeling tired* Diarrhea, nausea, vomiting, mouth sores, upset stomach, abdominal pain, and constipation. Talk with your doctor about ways to handle these problems.* The medicine in SUTENT is yellow, so it may make your skin look yellow. Your skin and hair may get lighter.* Your skin may become dry, get thicker, or crack. You may get blisters or a rash on the palms of your hands and soles of your feet.* Taste changes* Loss of appetite* Swelling* High blood pressure* Bleeding, such as nosebleeds or bleeding from cuts. Call your doctor if you have any swelling or bleeding.