Sitavig is a prescription antiviral medication used for the treatment of cold sores.Cold soresare another term for "oral herpes," a long-term infection of the mouth with the herpes simplex virus. Symptoms can include soreness, burning sensation, redness, ulcers, rashes, blisters, and tingling. Symptoms of oral herpes usually go away on their own but in some cases, may need treatment. Sitavig is an antiviral that works by incorporating into viral DNA to prevent the replication of viral particles. By preventing replication, the virus does not spread to healthy tissue, and symptoms will resolve more quickly. Sitavig will not cure oral herpes but treats the symptoms. Oral herpes is a long-term infection that is kept suppressed by the immune system. Fact Table Formula C8H11N5O3 License US FDA Bioavailability 15–20% Legal status Rx-only Chemical Name Aciclovir Elimination half-life 2–4 hours Dosage (Strength) 50mg Pregnancy No Known Risk Brands Sitavig, Zovirax Protein binding 9–33% PubChem CID 2022 MedlinePlus a681045 ChEBI 2453 ATC code R03AC18 DrugBank DB00787 KEGG D00222 Routes of administration By mouth