Before you administer Simparica TRIO to your dog, be sure you discuss the following with your veterinarian:, Your dog's medications, Your dog's allergies, Your dog's health conditions, If your dog is pregnant or may be pregnant, If your dog is nursing, Simparica TRIO should not be administered to humans, cats, or other animals., Neurological effects such as tremors, coordination problems, and seizures have been associated with the use of sarolaner, an active ingredient in Simparica TRIO. If your dog has a history of seizures or neurologic problems, use Simparica TRIO with caution. Your dog's medications, Your dog's allergies, Your dog's health conditions, If your dog is pregnant or may be pregnant, If your dog is nursing