Before starting treatment with Simbrinza, inform your doctor of the following:, All the medications you take, Any allergies you may have, Your medical history and active health problems, If you are pregnant or plan to become pregnant, If you are breastfeeding or plan to breastfeed, Brinzolamide, one of the active ingredients in Simbrinza, is a sulfonamide. Allergic reactions that may be severe can occur in patients who are allergic to sulfonamides. Seek medical care right away if you have trouble breathing, swelling, a rash, or other skin reaction., Swelling of the cornea can occur in patients with low endothelial cell counts while using Simbrinza., Brinzolamide, one of the active ingredients in Simbrinza, and its metabolite are excreted by the kidney; therefore, use of Simbrinza should be avoided in patients with severe kidney problems., Other therapies along with medications that lower fluid pressure in the eye(s) should be used to treat acute angle-closure glaucoma. The use of Simbrinza has not been studied in patients who have been diagnosed with acute angle-closure glaucoma., Caution should be used in patients with severe heart disease., Caution should be used in patients with severe liver problems because brimonidine tartrate, one of the active ingredients in Simbrinza, has not been studied in these patients., Caution should be used in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, low blood pressure upon standing, or thromboangitis obliterans because brimonidine tartrate, one of the active ingredients in Simbrinza, can cause syndromes related to vascular insufficiency. All the medications you take, Any allergies you may have, Your medical history and active health problems, If you are pregnant or plan to become pregnant, If you are breastfeeding or plan to breastfeed
