Your doctor may prescribe Rinvoq for severe active rheumatoid arthritis if you have already tried and failed other medications like methotrexate. Rinvoq is sometimes given along with methotrexate and other medications for rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disorder where the immune system attacks the joints, including the hands, knees, and feet. Symptoms include pain, stiffness, tenderness, and swelling in the joints. Rinvoq works by decreasing the activity of the immune system. By lowering the activity of the immune system, Rinvoq decreases symptoms of rheumatoid arthritis. Fact Table Formula C17H19F3N6O License US FDA, EU EMA Bioavailability 80% Legal status Rx-only Chemical Name Upadacitinib Elimination half-life 9–14 hours Dosage (Strength) 15mg Pregnancy Not Recommended Brands Rinvoq ER Protein binding 52% PubChem CID 58557659 MedlinePlus a619051 ChEBI - ATC code L04AA44 DrugBank DB15091 KEGG D10994 Routes of administration By mouth