The active ingredient of Revolution is selamectin. Fact Table Formula C43H63NO11 License US FDA Bioavailability 40.5% Legal status US: RX Only Chemical Name Selamectin Elimination half-life 11 days in dogs, 8 days in cats Dosage (Strength) Pink Kittens 0-5lbs (3 ampules), Pink Puppies 0-5lbs (3 ampules), Pink Kittens and Puppies (3 ampules), Blue Cats 5-15 lbs (3/6/12 ampules), Purple Dogs 5-10 lbs (3/6/12 ampules), Brown Dogs 10-20 lbs (3/6/12 ampules), Red Dogs 20-40 lbs (3/6/12 ampules), Green Dogs 40-85 lbs (3/6/12 ampules) Pregnancy Consult a doctor Brands Revolution, Stronghold, Revolt Protein binding - PubChem CID 9578507 MedlinePlus - ChEBI 177562 ATC code QP54AA05 DrugBank DB11459 KEGG D05813 Routes of administration Topical