PREMARIN (Conjugated Estrogens) is a medication prescribed to treat a variety of conditions. The approved PREMARIN tablet uses include: Prevention of postmenopausal osteoporosis for women at significant risk of osteoporosis, Palliative treatment of androgen-dependent carcinoma of the prostate in men, Palliative treatment of metastatic breast cancer in certain women, Treatment of low estrogen due to hypogonadism, castration, or ovarian failure, Treatment of moderate to severe symptoms of vulvar and vaginal atrophy caused by menopause, Treatment of moderate to severe vasomotor symptoms (night sweats, flushes, and hot flashes) PREMARIN works by regulating levels of several hormones, including estrogen, luteinizing hormone, and follicle-stimulating hormone. Fact Table Formula C18H19NaO5S License US FDA Bioavailability Variable Legal status Rx-Only Chemical Name Conjugated estrogens Elimination half-life 26.7 hours Dosage (Strength) 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg Pregnancy Not Recommended Brands Premarin Protein binding High PubChem CID 656613 MedlinePlus a682922 ChEBI - ATC code G03CA57 DrugBank DB00286 KEGG D04070 Routes of administration By mouth (Tablets)