Before you begin using Plenvu, inform your healthcare provider:, About all medications you are currently taking, especially medications for seizures, heart problems, or kidney conditions., About any medical conditions you have, particularly heart problems, kidney problems, seizures, gastric retention, bowel obstruction, or phenylketonuria (PKU). Plenvu contains phenylalanine, which can cause complications for people with PKU., If you are pregnant or plan to become pregnant. Plenvu's effects on an unborn baby are not known., If you are breastfeeding or plan to breastfeed. It is unknown whether Plenvu can pass into your breast milk., If you have Glucose-6-phosphate dehydrogenase deficiency (G6PD). Use Plenvu with caution., Plenvu may affect the absorption of other medications, including oral contraceptives, leading to their decreased effectiveness., Plenvu may cause changes in electrolyte levels and fluid balance. Seek immediate medical help if you experience seizures, irregular heartbeat, or increased thirst or urination, as these may be signs of serious fluid and electrolyte abnormalities., Plenvu may lead to serious allergic reactions, including anaphylaxis. Seek immediate medical attention if you experience trouble breathing, skin rash, itching, swelling of your face, lips, tongue, or throat., Suspected GI obstruction or perforation should be ruled out before administration., Patients with a history of cardiac arrhythmias should consider pre-dose and post-colonoscopy ECGs., Mucosal ulcerations may occur in patients with known or suspected inflammatory bowel disease., Plenvu should be administered under observation if you're at risk of aspiration. About all medications you are currently taking, especially medications for seizures, heart problems, or kidney conditions., About any medical conditions you have, particularly heart problems, kidney problems, seizures, gastric retention, bowel obstruction, or phenylketonuria (PKU). Plenvu contains phenylalanine, which can cause complications for people with PKU., If you are pregnant or plan to become pregnant. Plenvu's effects on an unborn baby are not known., If you are breastfeeding or plan to breastfeed. It is unknown whether Plenvu can pass into your breast milk., If you have Glucose-6-phosphate dehydrogenase deficiency (G6PD). Use Plenvu with caution.