Pifeltro is an antiviral medication that your doctor may prescribe for the treatment of human immunodeficiency virus (HIV-1) infection.HIVinfection causes Acquired Immunodeficiency Syndrome (AIDS), which is a long-term and fatal condition if not treated. When an HIV viral particle infects an immune system cell, it uses reverse transcriptase (RT) protein to replicate itself. Pifeltro works by incorporating into RT and stopping it from working. By shutting down RT, Pifeltro stops HIV viruses from replicating. Fact Table Formula C17H11ClF3N5O3 License US FDA Bioavailability 64% Legal status Rx-only Chemical Name Doravirine Elimination half-life 12-21h Dosage (Strength) 100mg Pregnancy Consult Doctor Brands Pifeltro Protein binding 76% PubChem CID 58460047 MedlinePlus a618048 ChEBI - ATC code J05AG06 DrugBank DB12301 KEGG D10624 Routes of administration By mouth