Ovestin HCT Cream Ovestin HCT cream contains the natural female hormone, oestriol. This cream contains the hormone Estriol which is a naturally occurring estrogen. Ovestin is used by post-menopausal women to relieve local symptoms of the vulva & vagina such as dryness and inflammation of the skin layer. Ovestin is used predominantly for the relief of symptoms caused by atrophy of the lower urogenital tract following the menopause. These include general vaginal/urinary symptoms, recurrent infections of the vagina and lower urinary tract, and mild urinary incontinence. Ovestin contains the natural hormone estriol, which is a weak estrogen. It treats urogenital symptoms without causing adverse changes to the endometrium, which means that it can be used without a progestogen in women with an intact uterus. The absence of progestogen-induced withdrawal bleeds with Ovestin makes it highly acceptable to women. As well as treating symptoms, the medicine has a preventive effect, having been shown to increase resistance to vaginal infection and inflammation.