When taking Osphena, some of the more common side effects can include: Angioedema, Cerebrovascular accident, Cysts, Deep vein thrombosis, Endometrial carcinoma, Endometrial hyperplasia, Endometrial polyps, Erythematous rash, Headache, Hot flash, Hyperhidrosis, Hypersensitivity reaction, Malignant neoplasm, Myocardial infarction, Night Sweats, Pruritus, Pulmonary embolism, Vaginal discharge, Vaginal hemorrhage Let your healthcare team know if you are experiencing any of the above side effects. You may need to stop the medication if symptoms are severe. Osphena. Florham Park, NJ: Shionogi Inc; 1/2019. Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy.Read More....