Before you start treatment with Nexletol, inform your doctor:, Of any medications you take. These include prescription and over-the-counter medications, vitamins, and herbal supplements., Of your allergies., Of your medical conditions., If you are pregnant or plan to become pregnant., If you are breastfeeding or plan to breastfeed., Avoid taking Nexletol with more than 20 mg of simvastatin or more than 40 mg of pravastatin., Nexletol can cause increased uric acid levels in the blood that can lead to gout., Nexletol can cause tendon rupture. Stop taking Nexletol and call your doctor right away if you experience joint pain, swelling, or inflammation. Of any medications you take. These include prescription and over-the-counter medications, vitamins, and herbal supplements., Of your allergies., Of your medical conditions., If you are pregnant or plan to become pregnant., If you are breastfeeding or plan to breastfeed.