Your doctor may prescribe Mytesi to treat non-infectious diarrhea in adult patients who have Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) from HIV. The patient must be on antiretroviral therapy. Mytesi works by inhibiting a protein in the intestines called cyclic adenosine monophosphate (cAMP)-stimulated cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. It also blocks calcium-activated chloride ion channels in the enterocyte luminal membrane. People with HIV/AIDS infection are at high risk for side effects like diarrhea when taking antiretrovirals. These types of medications are used to control HIV/AIDS infection. Fact Table Formula (C15O6,7H12)n License US FDA Bioavailability Little or no absorption from the gut Legal status AU, US: Rx Only Chemical Name Crofelemer Elimination half-life Not Determined Dosage (Strength) 125mg Pregnancy No Known Risks Brands Mytesi Protein binding - PubChem CID 347909853 MedlinePlus a613016 ChEBI - ATC code A07XA06 DrugBank DB04941 KEGG D03605 Routes of administration By mouth