Moduretic is a prescription that contains a combination of the drugs amiloride and hydrochlorothiazide. Your doctor may prescribe Moduretic to treat heart failure, hypertension, or both conditions. Hypertension is another term for high blood pressure. Hypertension is a chronic condition where the blood pushes too forcefully on the blood vessel walls. Over time, the increased pressure can cause organ damage, heart attack, or stroke. In heart failure, one or more chambers of the heart cannot squeeze hard enough to push blood through the blood vessels. Blood may pool in the limbs or lungs, impacting the quality of life. Fact Table Formula C6H8ClN7O License US FDA Bioavailability Readily absorbed, 15–25% Legal status Rx-only Chemical Name Amiloride Elimination half-life 6 to 9 hours Dosage (Strength) 5/50mg Pregnancy Consult Doctor Brands Moduretic Protein binding ~23% PubChem CID 16231 MedlinePlus a615029 ChEBI 2639 ATC code C03DB01 DrugBank DB00594 KEGG D07447 Routes of administration By mouth