Minocin 100 mg needs to be taken orally with a full glass of water. The usual dosage of the drug is one tablet in every 12 hours. It is important you take it on an empty stomach, at least 1 hour before a meal or 2 to 3 hours after one. In case you experience stomach upsets, you may take it with food or milk, but Minocin tends not to work so well when taken with a meal. Take the medication with correct intervals for best results. Minocin capsules need to be taken as a whole, do not chew, break or bite. Do not lie down for at least 10 minutes after taking the drug which means avoid using the medication right before bedtime. Avoid using antacids, vitamin supplements, dairy products, and calcium-rich juices along with Minocin as these substances tend to decrease the effectiveness of this drug.