Some of the most common adverse reactions to this medication may include: Abdominal distention, Abdominal pain, Abnormal uterine bleeding, Accidental injury, Acne vulgaris, Anxiety, Arthralgia, Asthenia, Back pain, Breakthrough bleeding, Breast hypertrophy, Breast tenderness, Bronchitis, Cervical polyp, Constipation, Depression, Dizziness, Dysmenorrhea, Dyspepsia, Edema, Endometrium disease, Fatigue, Flatulence, Flu-like symptoms, Fungal infection, Gastroenteritis, Headache, Hirsutism, Hot flashes, Hypertension, Intermenstrual bleeding, Leukorrhea, Limb pain, Mastalgia, Myalgia, Nasopharyngitis, Nausea, Neck pain, Nipple pain, Pain, Paranasal sinus congestion, Pharyngitis, Pruritus, Rhinitis, Sinus headache, Sinusitis, Skin rash, Upper respiratory tract infection, Urinary tract infection, Uterine pain, Vaginal discharge, Vaginal hemorrhage, Vaginal mycosis, Vulvovaginal candidiasis, Weight gain If you experience any of the above side effects, do not immediately stop your medication, but call your doctor and pharmacist. Certain side effects are temporary, but some may lost long term in certain people. Minivelle(Estradiol) Miami, FL: Noven Pharmaceuticals Inc.; 2012. Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy.Read More....