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Migranal Nasal Spray (Dihydroergotamine)
Dihydroergotamine Mesylate is often prescribed for the treatment ofmigraines and headacheswhen other forms of treatment have not been successful. It is inhaled through the nostrils to provide quick relief of headaches as they start. Dihydroergotamine Mesylate works by tightening the blood vessels in the brain, which leads to a decrease in pain signals. If blood vessels are too relaxed, this can push into the surrounding tissue and cause inflammation that leads to headaches. Fact Table Formula C33H37N5O5 License US FDA, EU EMA Bioavailability 32% Legal status Rx-only Chemical Name Dihydroergotamine Elimination half-life 9 hours Dosage (Strength) 0.5mg Pregnancy Consult Doctor Brands Migranal, Trudhesa Protein binding 93% PubChem CID 10531 MedlinePlus a603022 ChEBI 4562 ATC code N02CA01 DrugBank DB00722 KEGG D07837 Routes of administration Nasal

Migranal Nasal Spray (Dihydroergotamine)

  • The standard dosage is to inhale one inhalation through the nose at the onset of symptoms. Repeat every hour as needed, do not exceed 3 mg per 24 hour period. Do not exceed 6 mg in a week. Taking more than the recommended maximum can lead to rebound headache and worsening of pain and other symptoms.
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