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Siklos is prescribed to treat painful crises in people withsickle cell anemiawho are two years of age or older. Sickle cell anemia is a disease of the red blood cells that cause them to be misshaped. Siklos works through several mechanisms to help restore red blood cells' proper functioning and shape. Fact Table Formula CH4N2O2 License US FDA, EU EMA Bioavailability 79% Legal status Rx-only Chemical Name Hydroxyurea Elimination half-life 2–4 hours Dosage (Strength) 100mg Pregnancy Consult Doctor Brands Medunik Protein binding More than 76% PubChem CID 3657 MedlinePlus a682004 ChEBI 44423 ATC code L01XX05 DrugBank DB01005 KEGG D00341 Routes of administration By mouth

Medunik (Hydroxyurea)

  • The starting dosage is 20 mg per kilogram and may be increased as needed. If bone marrow suppression occurs, Siklos should be discontinued until blood counts return to an acceptable range. Do not stop taking Sikos or change the dose without speaking with your doctor.
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