MATULANE (Procarbazine) is a prescription chemotherapy medication that treats certain types of cancers. MATULANE should only be used under the close supervision of an oncologist. MATULANE is indicated for the treatment of Stage III and Stage IV Hodgkin’s disease. When treating Hodgkin’s disease, it should be used in combination with nitrogen mustard, vincristine, and prednisone (MOPP regimen). MATULANE can also be used off-lab to treat CNS tumors, Non-Hodgkin lymphomas, and primary CNS lymphoma. MATULANE works by preventing the replication of human cells by stopping the synthesis of DNA, RNA, and proteins. MATULANE targets cancer cells but can also affect non-cancerous cells. Fact Table Formula C12H19N3O License US FDA Bioavailability - Legal status Rx-only Chemical Name Procarbazine Elimination half-life 10 minutes Dosage (Strength) 50mg Pregnancy Not recommended Brands Matulane, Natulan Protein binding - PubChem CID 4915 MedlinePlus a682094 ChEBI 71417 ATC code L01XB01 DrugBank DB01168 KEGG D08423 Routes of administration By mouth