Lumakras is a prescription medication for treating advanced or metastatic non-small cell lung cancer (NSCLC) with a specific genetic mutation called KRAS G12C. This mutation is present in about 13% of NSCLC cases and has historically been difficult to target with traditional treatments. Lumakras works by inhibiting the activity of the mutated KRAS protein, which is a gene responsible for the uncontrolled growth and spread of cancer cells. Lumakras attaches to the protein made by this gene mutation, rendering the protein inactive, which inhibits cancerous cell growth. Fact Table Formula C30H30F2N6O3 License US DailyMed Bioavailability - Legal status Rx-Only Chemical Name Sotorasib Elimination half-life 5 hours Dosage (Strength) 120mg Pregnancy Consult Doctor Brands Lumakras Protein binding - PubChem CID 137278711 MedlinePlus a621036 ChEBI 178199 ATC code L01XX73 DrugBank DB15569 KEGG D12055 Routes of administration By mouth

Lumakras (Sotorasib)

The usual dosage is 960 mg by mouth once daily. Lumakras should be taken with or without food.
Do not use Lumakras if you do not have the KRAS G12C mutation. It is not effective in treating other types of lung cancer. Tell your healthcare provider if you have a history of lung or breathing problems before using Lumakras. The medication can cause lung inflammation, which can be serious or life-threatening. Your healthcare provider should administer a liver function test every three weeks for the first three months of treatment.
Common side effects may include: Edema, Skin rash, Decreased serum albumin, Decreased serum calcium, Decreased serum sodium, Abdominal pain, Decreased appetite, Diarrhea, Nausea, Vomiting, Increase in urinary protein, Decreased hemoglobin, Lymphocytopenia, Prolonged partial thromboplastin time, Hepatotoxicity, Increased serum alanine aminotransferase, Increased serum alkaline phosphatase, Increased serum aspartate aminotransferase, Fatigue, Arthralgia, Musculoskeletal pain, Cough, Dyspnea, Pneumonia, Cardiac failure, Gastric ulcer, Interstitial pulmonary disease, Pneumonitis, Respiratory failure

Lumakras (Sotorasib)

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