Before you begin treatment with Lokelma, discuss the following with your doctor:, All the prescription and nonprescription medications you take, including herbals, vitamins, and supplements., Your allergies., Your current health problems and past medical history., If you are pregnant or breastfeeding., Patients with severe constipation, bowel obstruction or impaction, or any other gastrointestinal motility problem should not take Lokelma., Because Lokelma contains sodium, swelling can occur in some patients, particularly at higher doses of the medication. Patients should monitor for signs and symptoms of swelling, especially if they are on a low-sodium diet or have heart failure or kidney disease., Low potassium levels in the blood may occur in hemodialysis patients who are taking Lokelma., Lokelma may appear as an imaging agent during X-rays on the abdominal region. All the prescription and nonprescription medications you take, including herbals, vitamins, and supplements., Your allergies., Your current health problems and past medical history., If you are pregnant or breastfeeding.