Patients using Kombiglyze XR mostly complained of having: A headache, Flu-like symptoms, Soreness in the back of the nose and throat and discomfort when swallowing, Difficulty breathing or tightness in the chest, Vomiting or diarrhoea, Stomach pain or discomfort, Swelling of hands, ankles or feet, Signs of urinary tract infection, Rash, Feeling depressed or anxious, Signs of anaemia, Loss of appetite, Loss of taste, Increased blood pressure, Back pain, Joint pain Signs of hypoglycemia, Severe allergic reaction, Severe upper stomach pain, with nausea and vomiting, Signs and symptoms of heart failure (increased shortness of breath, a rapid increase in weight and swelling of the feet).