Serious Warnings and Precautions The use of INHIBACE (cilazapril) is contraindicated during pregnancy (see CONTRAINDICATIONS). When used in pregnancy, angiotensin converting enzyme (ACE) inhibitors can cause injury or even death of the developing fetus. Pregnant women should be informed of the potential hazards to the fetus and must not take INHIBACE during pregnancy. Patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy. When pregnancy is detected, INHIBACE should be discontinued as soon as possible and, if appropriate, alternative therapy should be started. Before Inhibace treatment is initiated, the following should be discussed with your doctor:, All the medications you take, including prescription and nonprescription medications, vitamins, and herbal supplements, Any allergies you may have, Your medical history and current health conditions, If you are pregnant, think you are pregnant, or have plans to become pregnant, If you are breastfeeding or plan to breastfeed, Angioedema can occur with Inhibace treatment. Black-skinned patients and patients who have had angioedema before have a greater risk. Seek medical care right away if you develop swelling, hives, or trouble breathing., Inhibace should be used with caution if you have obstructive cardiac problems such as mitral stenosis, aortic stenosis, and hypertrophic cardiomyopathy. Severe low blood pressure can occur., Low blood pressure can occur with Inhibace treatment. Monitor your blood pressure regularly., Taking Inhibace with aliskiren can increase the risk of low blood pressure, fainting, stroke, high potassium levels, and kidney problems in patients who have diabetes and/or moderate to severe kidney impairment., Some patients may develop a dry cough with Inhibace treatment. The cough generally disappears if the dose is lowered or Inhibace is stopped., Inhibace may increase the blood sugar lowering effects of oral diabetes medications or insulin. Patients with kidney problems are at greater risk. Blood sugar levels should be monitored as instructed by the doctor., Inhibace does not work as well in black-skinned patients of African descent., Treatment with Inhibace may lead to low counts of certain types of white blood cells, including neutrophils and granulocytes., Treatment with Inhibace can cause liver problems such as hepatitis, jaundice (yellowing of the skin or whites of the eyes), increased liver enzymes, or increased bilirubin levels., Treatment with Inhibace can cause high potassium levels, especially in patients with kidney problems and/or in patients taking potassium-sparing diuretics or medications that contain potassium., Treatment with Inhibace can cause anaphylactoid reactions when exposed to membranes such as during dialysis with high-flux membranes., Treatment with Inhibace can cause anaphylactoid reactions during low density lipoproteins (LDL) apheresis with dextran sulfate., Treatment with Inhibace can cause anaphylactoid reactions during desensitizing treatment with bee/wasp venom., Patients who receive injectable gold and are taking Inhibace are at risk for nitroid reactions that can cause facial flushing, nausea, vomiting, and symptomatic low blood pressure., Inhibace can cause low blood pressure during surgery or anesthesia., Treatment with Inhibace can cause kidney problems in some patients., Lactose monohydrate is contained in Inhibace tablets. Patients who cannot tolerate galactose, cannot properly absorb glucose-galactose, or have Lapp lactase deficiency should avoid taking Inhibace., Inhibace can cause harm to an unborn fetus; therefore, pregnant or breastfeeding women should avoid taking Inhibace. All the medications you take, including prescription and nonprescription medications, vitamins, and herbal supplements, Any allergies you may have, Your medical history and current health conditions, If you are pregnant, think you are pregnant, or have plans to become pregnant, If you are breastfeeding or plan to breastfeed
