Before you begin treatment with Imbruvica, you should discuss the following with your doctor:, All the medications you take, Your allergies, Your medical history and health problems, Your pregnancy or breastfeeding status, Severe bleeding can occur with the use of Imbruvica. You should seek immediate medical care if you have black, tarry stools; bleeding from the gums; blood in your vomit; nosebleeds that won't stop after 10-15 minutes of applied pressure; or experienced a fall or head trauma., Infections can occur with the use of Imbruvica., Serious heart arrhythmias, heart failure, and sudden death can occur with the use of Imbruvica., High blood pressure can occur with the use of Imbruvica., Abnormal blood cell counts can occur with the use of Imbruvica., Skin cancers and other malignancies have occurred with the use of Imbruvica., Although rare, tumor lysis syndrome can occur with the use of Imbruvica., Imbruvica can cause harm to an unborn baby. Women who take Imbruvica should use effective birth control methods during treatment and for one month after stopping Imbruvica. All the medications you take, Your allergies, Your medical history and health problems, Your pregnancy or breastfeeding status