Some common side effects of this drug include: Headache, Breast pain, Irregular vaginal bleeding or spotting, Stomach/abdominal cramps, bloating, Nausea and vomiting, Hair loss However, if you undergo any serious side effects as mentioned below then notify your doctor immediately. Breast lumps, Unusual vaginal bleeding, Dizziness and faintness, Changes in speech, Severe headaches, Chest pain, Shortness of breath, Pain in your legs, Changes in vision, Vomiting Some very rare but more serious side effects include: Breast cancer, Cancer of the uterus, Stroke, Heart attack, Blood clots, Gallbladder disease, Ovarian cancer Notify your doctor right away if you undergo any side effects. Fact Table Formula C18H24O2 License EU EMA Bioavailability Oral: less than 5% Legal status RX Only Chemical Name Estradiol Elimination half-life Oral: 13–20 hours, Sublingual: 8–18 hours, Topical (gel): 36.5 hours Dosage (Strength) 0.06% get (80 grams) Pregnancy Consult a doctor Brands Estrogel, Estradiol Transdermal Cream Protein binding 98% PubChem CID 5757 MedlinePlus a601121 ChEBI 16469 ATC code G03CA03 DrugBank DB00783 KEGG D00105 Routes of administration Inserted