Some common side effects of Estrace vaginal cream that may go away after treatment include: Vaginal irritation, Dizziness, Lightheadedness, Headache, Stomach upset, Bloating, Nausea, Weight change, Increased or decreased interest in sex, Breast tenderness Keep in mind that your doctor has prescribed you this medication because its benefits to you are greater than the risk of side effects. Many people who use this medication do not have serious side effects. However, if you undergo any serious side effects as mentioned below then notify your doctor immediately. Mental or mood changes, Severe depression, Calf pain or swelling, Sudden, severe headache, Chest pain, Trouble breathing, One-sided weakness, Slurred speech, Vision changes, Change in contact lens fit, Loss of vision, Breast lumps, Swelling of hands or feet, Changes in vaginal bleeding, breakthrough bleeding, or prolonged bleeding, Unusual vaginal discharge, Itching, or odor, Yellowing of eyes or skin. An allergic reaction to this drug is very rare; however, if you notice any symptoms such as itching, rash, swelling or trouble breathing; visit your doctor right away.