ESTRACE (Estradiol) cream is a medication prescribed to treat vulvar and vaginal atrophy associated with menopause. ESTRACE work by attaching to estrogen receptors in vaginal cells, which reduces vaginal pH, improving symptoms of dryness and mucosal atrophy. After menopause, the natural levels of estrogen decrease. Dryness and atrophy are common symptoms that occur with the onset of menopause. ESTRACE cream helps to replace endogenous estrogens that are no longer being produced.