ENTRESTO may cause serious side effects including: angioedema that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO. People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema low blood pressure (hypotension). Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue kidney problems increased amount of potassium in your blood The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.