Call the doctor at once if any of the following side effects are seen with Depakene. Diarrhea, Dizziness, Hair loss, Blurred or double vision, Changes in menstrual periods, Ringing in the ears, Shakiness, tremors, unsteadiness, Weight changes, Depression, Suicidal thoughts or attempts, Confusion, tiredness, cold feeling, Easy bruising, unusual bleeding from nose, mouth or gums, Purple or red pinpoint spots under the skin, Worsening seizures, Signs of inflammation, Severe skin reaction, Loss of appetite, Vision problems, Swelling of hands and feet, Memory problems, Sleep problems, insomnia, Nausea, vomiting, Diarrhea, constipation, Stomach pain, Fever, flu symptoms