Talk to your health professional about the following conditions to make sure you can safely take CYMBALTA: liver or kidney disease, seizures or epilepsy, bleeding or blood clotting disorder, glaucoma, bipolar disorder (manic depression), history of drug abuse or suicidal thoughts, use of any prescription, nonprescription and herbal medications, use of any NSAID pain relievers, aspirin, or blood thinners, about your alcohol use, your blood pressure, if you are pregnant or plan to become pregnant during therapy, or are breast-feeding suicidal thoughts, especially in patients younger than 24 years old, mood changes, increased pressure on your eyes (narrow-angled glaucoma), impaired thinking and/or reactions, bleeding when taken with other NSAID medications, complications in your pregnancy and breastfeeding, increased sensitivity to side effects for older patients, heightened blood pressure The following should be avoided while taking CYMBALTA: drinking alcohol as it may increase the risk of liver damage, operating heavy machinery, driving, any activity that requires you to be alert (until your body has adjusted to the medication)