Before Credelio Plus is administered to your dog, tell your vet about your dog's:, Medications, Allergies, Medical history and health problems, Pregnancy or nursing status, Lotilaner, an isoxazoline, has been associated with neurological adverse reactions such as tremors, balance and coordination problems, and seizures. Seizures can occur in dogs that don't have a history of seizures. Caution should be used, especially in dogs with a history of seizures or neurological problems. Medications, Allergies, Medical history and health problems, Pregnancy or nursing status