CombiPatch has a FDA Boxed Warning against the use of estrogens and progestins for preventing cardiovascular disease or dementia. The FDA Boxed Warning also warns that estrogen plus progestin therapy can increase the risk of blood clots in the legs or lungs, stroke, and heart attack in postmenopausal women. Further, the FDA Boxed Warning warns that estrogen plus progestin therapy can increase the risk of dementia and breast cancer in women. Estrogen alone has been shown to increase the risk of endometrial cancer in women with a uterus. Estrogen alone has also been shown to increase the risk of stroke, blood clots, and dementia in postmenopausal women. Estrogens with or without progestins should be used at the lowest dose possible and for the shortest duration of time while meeting treatment goals. Before you start treatment with CombiPatch, be sure to inform your doctor:, Of any medications you take, Your allergies, Your health history and medical problems, If you are pregnant or breastfeeding, The risk of gallbladder disease that requires surgery is increased in postmenopasual women who are taking estrogens., High calcium levels can occur in women who have breast or bone cancer and are taking estrogens., Blood clots in the retina of the eyes can occur in women who take estrogens., Swelling of the eyes, face, tongue, legs, ankles, or fingers can occur with the use of CombiPatch. Seek medical care immediately if any of these occur., Severe allergic reactions that include hives, itching, or swelling can occur with the use of CombiPatch. Seek medical care immediately if any of these occur., Estrogens may cause an increase in blood pressure., Estrogens may increase triglyceride levels in the blood that can lead to pancreatitis., Women who are taking estrogens and thyroid hormone replacement therapy may need a dose increase in their hormone replacement therapy., Fluid retention can occur with the use of estrogens., Worsening of asthma, diabetes, seizures, migraines, lupus, and benign liver tumors can occur with the use of estrogens. Caution should be used in women who have any of these conditions. Of any medications you take, Your allergies, Your health history and medical problems, If you are pregnant or breastfeeding
