AVODART (Dutasteride) is a medication prescribed to treat symptoms ofbenign prostatic hyperplasia (BPH)in men who have anenlarged prostate. AVODART can help to improve symptoms, reduce urinary retention, and reduce the need for BPH surgery. AVODART is also approved for the treatment of BPH in combination with the prescription medicationtamsulosin. Dutasteride works by preventing the conversion of testosterone todihydrotestosterone (DHT). As men age, a larger portion of their testosterone is converted to DHT, which is responsible for enlarging the prostate. Dutasteride inhibits the enzyme 5-alpha-reductase, which catalyzes the conversion reaction.