Side effects associated with amantadine are generally mild and, when they do occur, often cease after a week or more of taking the medication. Amantadine may cause some unwanted, and unusual side effects including increased sexual urges, urges to gamble or other unusual, intense urges. Talk to your doctor if these occur.Additionally, if you experience any of the following symptoms when taking amantadine, contact your doctor immediately: Bloody or cloudy urine, Difficulty, burning or painful urination, Bladder pain, Frequent urge to urinate, Confusion, Swelling of the hands, feet or lower legs, Hallucinations, Dizziness or lightheadedness, Fainting Older adults taking amantadine may experience: Dry mouth, Swelling of the feet or legs,, Dizziness, Constipation, Nausea, Insomnia Common side effects of amantadine include: Headaches, Nausea, Irritability, Loss of appetite, Insomnia, Anxiety, Difficulty concentrating Find out More About Amantadine Side Effects You should seek emergency medical attention if you encounter signs of an allergic reaction which can include hives, difficulty breathing, or swelling of the face, lips, tongue or throat.If when taking amantadine you notice that you are experiencing extreme drowsiness, lightheadedness, shortness of breath, difficult or painful urination, changes to your mental health (including signs ofdepressionor aggression), severe nervous system reactions (stiff, rigid muscles, sweating, high fever, confusion) seek emergency medical attention.