WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER, ENDOMETRIAL CANCER AND PROBABLE DEMENTIA See full prescribing information for complete boxed warning Estrogen Plus Progestin Therapy Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia, The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke and myocardial infarction (MI), The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer, The WHI Memory Study (WHIMS) estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmeno- pausal women 65 years of age and older Estrogen-Alone Therapy, There is an increased risk of endometrial cancer in a woman with a uterus who use unopposed estrogens, Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia, The WHI estrogen-alone substudy reported increased risks of stroke and DVT, The WHIMS estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older Be sure to discuss the following with your doctor before you begin treatment with Activella:, All the medications you take. These include prescription and over-the-counter medications in addition to vitamins and herbal supplements., Your allergies., Your health conditions and medical history., If you are pregnant, think you are pregnant, or plan to become pregnant., If you are nursing or plan to nurse your baby., Your risk for gallbladder problems may be increased with the use of Activella., Seek medical care immediately if you experience vision loss during treatment with Activella. Be sure to discuss the following with your doctor before you begin treatment with Activella:, All the medications you take. These include prescription and over-the-counter medications in addition to vitamins and herbal supplements., Your allergies., Your health conditions and medical history., If you are pregnant, think you are pregnant, or plan to become pregnant., If you are nursing or plan to nurse your baby., Your risk for gallbladder problems may be increased with the use of Activella., Seek medical care immediately if you experience vision loss during treatment with Activella. All the medications you take. These include prescription and over-the-counter medications in addition to vitamins and herbal supplements., Your allergies., Your health conditions and medical history., If you are pregnant, think you are pregnant, or plan to become pregnant., If you are nursing or plan to nurse your baby. Seek medical care immediately if you develop yellowing of your skin or whites of your eyes during treatment with Activella. Activella can cause high levels of calcium in women who have breast cancer or bone cancer. Activella can cause high levels of triglycerides in the blood that an lead to pancreatitis. Activella can cause high blood pressure. Activella can cause high blood pressure. If you are on thyroid replacement therapy, your thyroid function should be checked during treatment with Activella. Activella can cause low blood calcium levels in women who have hypoparathyroidism., Activella can cause fluid retention., Activella can worsen the symptoms of certain conditions such as hereditary angioedema, asthma, diabetes, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas. Caution should be used in women who have these conditions.
